Job Description
The Downstream Processing Technician plays a crucial role in supporting the manufacturing operations of Commercial and Clinical Biologics. The technician will adhere to Current Good Manufacturing Practices (cGMPs) and perform a variety of downstream functions, including propagation of mammalian cell culture, aseptic cell culture operations, execution of large-scale production bioreactors, and large-scale filtration or centrifugation. Purification duties will involve large-scale chromatography, including column and HPLC techniques. The technician will manufacture buffers and simple bulk reagents with limited supervision and participate in process improvement projects.
ResponsibilitiesReview all area documents.Responsible for the WNS.Assist in the manufacture of controls and calibrators and complete batch records following cGMPs.Perform in-process assays using equipment such as spectrophotometers, pH meters, and clinical analyzers.Weigh, transfer, and mix chemicals as required.Perform product filtrations.Clean and steam steel tanks (CIP/SIP).Prepare glassware and steel tanks for sterilization in autoclave and operate the autoclave.Maintain lab equipment, including pumps, pH meters, and flow meters.Keep department lead or manager updated on all issues.Monitor stocks of common lab supplies.Perform other job duties as required.Respond to emergency notifications.Work flexible hours, including weekends.Essential SkillsKnowledge of cleanroom and aseptic techniques.Bachelor's Degree in Science with expertise in aseptic technique, chemistry, HPLC, and chromatography.Minimum of 2 years of work experience in manufacturing, operation, production, lab setting, or related field.Additional Skills & QualificationsPreferred: 6 months experience in GMP regulated environment and aseptic technique.Preferred: Experience in a cGMP environment and a 4-year STEM degree.Knowledge of cGMP practices, aseptic techniques, or chemical concepts.Work Environment
The work environment involves cleanroom and aseptic suites, requiring the willingness to gown up. The position operates on a day shift from 6:15 am to 6:45 pm, with rotating 12-hour shifts working 7 days out of a 2-week period. Technicians must be willing to wear full gowning suits, including bodysuits, gloves, hair & beard nets, face covers, and safety glasses. Restrictions on makeup, jewelry, nail polish, cologne/perfume, scented lotions, or hair care products apply. Ability to lift a minimum of 25 lbs independently and stand for 80% of the shift is required.
Pay and Benefits
The pay range for this position is $27.00 - $28.00/hr.
Eligibility requirements apply to some benefits and may depend on your job
classification and length of employment. Benefits are subject to change and may be
subject to specific elections, plan, or program terms. If eligible, the benefits
available for this temporary role may include the following:
• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)
Workplace Type
This is a fully onsite position in Saint Louis,MO.
Application Deadline
This position is anticipated to close on Aug 22, 2025.
About Actalent
Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.
The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.
If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.