At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Lilly Small Molecule Discovery group is an organization purpose-built to create molecules that make life better for people. We focus on using cutting edge science to unlock new approaches that can treat people suffering from diseases with poor treatment options. We are dedicated to optimizing our mindset, technology, and processes for faster, more nimble execution. Our success is built on a culture that empowers innovative problem solving through open collaboration and individual accountability. 

Discovery Technology and Platforms is a newly established function within this organization. Its mission is to accelerate molecule discovery by building highly optimized teams, streamlining lab operations through advanced technologies and data connectivity, and intentionally investing in novel technologies and capabilities. 

Position Summary:

The Molecular Craftsman within the Molecular Discovery Foundational Platform will lead multi-disciplinary teams to accelerate small molecule design and discovery using modern property-based drug design and various technologies. This role requires a strong blend of scientific vision, operational agility, and collaborative leadership. The ideal candidate will be a creative thinker and doer with a proven track record delivering high quality molecules into the clinic. We are seeking a highly skilled and experienced Medicinal Chemist and team player to join the Molecular Discovery group located at the Lilly Seaport Innovation Center (LSC), a research and development facility in the Boston Seaport . This role requires excellent scientific judgment, leadership, and a tenacious desire to bring meaningful medicines to patients.

Responsibilities:

Lead focused multidisciplinary teams with tenacity to solve challenging problems to deliver meaningful medicines that change the lives of patients.

Leverage world-class technologies with internal/external expert partners to craft the drugs of the future via de-novo molecular design.

Lead a small, focused team of experienced medicinal chemists and drive the development and impact of the team

Keep scientific rigor, urgency and impact as your top priority always.

Formulate hypothesis, design and lead the external syntheses of novel small molecules to advance drug discovery programs into the clinic.

Optimize compounds to improve physicochemical properties, potency, selectivity and ADME/DMPK to meet the desired target product profiles required for high-quality medicines.

Engage and collaborate across many scientific disciplines to drive success with aggressive timelines.

Minimum Requirements:

PhD in Organic or Medicinal Chemistry with >10 years post-graduation experience in small molecule programs in either biotech or pharmaceutical industry.

Project leadership example(s), coordinating multiple scientific activities and team members simultaneously across various disciplines to deliver small molecules into development.

Extensive experience in modern, property-based drug design using medicinal chemistry knowledge, SAR analysis, x-ray or cryo-EM structures and computer-assisted modeling

Additional Skills and preferences

Excellent and extensive working knowledge of modern, property-based drug design and discovery within high functioning departments and/or teams.

Excellent English language oral and written communication skills, ability to engage highly effectively as team player in a multidisciplinary and international environment.

Scientific creativity and curiosity with the ability to challenge people/teams in a respectful manner

Strong work ethic. Scientific curiosity. Tenacious attitude.

Work Environment: 

This position’s work environment is an office environment.  The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. 

To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. 

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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