**Description** A key scientific member and leader within the Oncology Research group at Boehringer Ingelheim’s US research facility in Ridgefield, CT, the successful candidate will spearhead research activities focusing on biology- and target-specific modeling and mechanism of action (MOA) interrogation to support in vivo target validation, candidate selection and biomarker discovery of novel cancer immune reprogramming therapeutic concepts for Boehringer’s global Oncology Research TA. As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies´ success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim´s high regard for our employees **Duties & Responsibilities** + Functioning as In vivo Pharmacology Lead on portfolio projects to generate data packages for target validation, compound screens, efficacy, human dose estimation, and candidate selection, as well as to explore MOA and PD biomarkers for both large molecules and small molecule compounds. + Develop and refine existing in vivo modeling systems to evaluate cancer immune reprogramming new therapeutic concepts (NTCs) with increased clinical relevance. + Closely collaborate with NTC project leads (Ridgefield or Vienna based team members in Oncology Research) to develop novel modeling methodologies to assess target- and pathway-specific immune reprogramming effects of NTCs in vivo and ex vivo. + Collaborate extensively with other members of the Project Teams from other disciplines located in Ridgefield, and globally in, Austria and Switzerland to enable key milestone movements and program decisions on NTCs, while synergizing effectively with the global in vivo pharmacology group of Oncology Research in Vienna, Austria. + Independently responsible for authoring IACUC approved animal protocols and ensuring their authorization, compliance and maintenance. + Train and direct research scientists - will have supervisory responsibilities, including, managing, mentoring, developing (and recruiting) scientific staff. Ensure team maintains compliance of IACUC protocols and health and safety regulations. + Prepare and review clear and accurate technical and research reports for internal and external use. Prepare and deliver scientific presentations for internal/external use. Act as an experienced and expert resource in project teams and demonstrate clear and professional verbal and written communication. + Continue to develop scientific expertise, credentials and drug development expertise by keeping abreast of relevant literature, by expanding scientific/technical knowledge and skill sets, and by publishing in peer-reviewed journals and speaking at internationally-recognized scientific conferences. **Requirements** **Principal Scientist:** + Ph.D. from an accredited institution, or equivalent in relevant field, with five-plus (5+) years of experience in addition to experience in lab management + Proven track record of supervising scientists and students. + Strong understanding of immunological principles through experience in cancer immunology, inflammation, or autoimmunity, with exceptional hands on in vivo experimental skills is required. + Strong understanding of principles of cancer immunology and prior hands-on experience running mouse models of immunotherapy (e.g. syngeneic mouse tumor models, humanized tumor models) is highly desired. + Demonstration of familiarity and understanding of Institutional animal ethics governance bodies (USA based IACUC or European based FELASA) through active responsibilities on animal licenses or protocols as Study Director or Principal Investigator is required. + A demonstrated track record of independent research and peer-reviewed publications in key areas of immunology is required. + Excellent oral and written communication skills, with the ability to propose, articulate, evaluate and defend scientific ideas and data. + The ability to mentor and develop scientific staff + The ability and willingness to work effectively in a highly collaborative research environment - with colleagues in Austria, Germany, Switzerland and the USA including occasional travel to global research sites. **Senior Principal Scientist:** + Ph.D. from an accredited institution, or equivalent in relevant field, with seven-plus (7+) years of experience in addition to experience in lab management + Strong leadership of a team with demonstrated influence on cross function, matrixed team environment. + Prior hands-on experience of generating in vivo models to assess aspects of cancer immune reprogramming is a must. + Experience with efficacy and pharmacokinetic/pharmacodynamics (PK/PD) and biomarker studies is a plus. + Principal Investigator on a USA IACUC protocol or European based FELASA documents is required. **Compensation** :  This position, Principal Scientist, offers a base salary typically between $140,000.00 and $222,000.00.  The position may be eligible for a role specific variable or performance based bonus and or other compensation elements. For an overview of our benefits please click here. (https://www.boehringer-ingelheim.com/us/careers/benefits-rewards) **Eligibility Requirements:** + Must be legally authorized to work in the United States without restriction at commencement of role. + Must be willing to take a drug test and post-offer physical (if required) + Must be 18 years of age or older All qualified applicants will receive consideration for employment without regard to a person’s actual or perceived race, including natural hairstyles, hair texture and protective hairstyles; color; creed; religion; national origin; age; ancestry; citizenship status, marital status; gender, gender identity or expression; sexual orientation, mental, physical or intellectual disability, veteran status; pregnancy, childbirth or related medical condition; genetic information (including the refusal to submit to genetic testing) or any other class or characteristic protected by applicable law.