Job Title: Sr Manager, RWE Analytics Location: Plainsboro, NJ Hybrid - 3 days onsite, 2 days work from home Work Schedule: Mon–Fri, 8:30 AM–5:30 PM (45 hours/week) Job Summary The Senior Scientist, Health Economic Resources (Sr Manager, RWE Analytics) will support the design, execution, and communication of real-world evidence studies using claims, EHR, registry, and linked data sources. This role provides hands-on analytics, AI/ML support, and contributes to evidence for clinical development, market access, safety, and regulatory objectives. Responsibilities + Support observational study design, execution, and communication. + Conduct hands-on RWE analytics using claims, EHR, registries, and emerging RWD. + Perform feasibility assessments of new data modalities (SDOH, genomics, biomarkers, clinical notes). + Develop analytic data files, table shells, QC, programming, and statistical outputs. + Lead or support AI/ML pilots and scale analytic frameworks. + Partner cross-functionally with development, commercial, market access, medical affairs, safety, and legal. + Draft analysis reports, manuscripts, and conference presentations. + Manage external research partners/vendors. Required Qualifications + PhD or Master’s in Epidemiology, Biostatistics, Public Health, or related field. + 3+ years’ real-world evidence and epidemiology analytics experience. + Experience with claims, EHR, hospital billing, SEER, and linked datasets. + Strong understanding of epidemiologic/statistical concepts (bias, confounding, incidence, regression, survival analysis, causal inference). + Proficiency with SAS, R, Python; AI/ML experience preferred. + Oncology experience preferred. + Strong communication and collaboration skills. + Ability to excel in a fast-paced environment with tight timelines. System One, and its subsidiaries including Joulé, ALTA IT Services, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan. System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law. #M- #LI- #DI- Ref: #568-Clinical System One, and its subsidiaries including Joulé, ALTA IT Services, CM Access, TPGS, and MOUNTAIN, LTD., are leaders in delivering workforce solutions and integrated services across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible full-time employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan. System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.