At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

This Opportunity

Support drug discovery and early development by applying DMPK/PD and modeling & simulation concepts, starting from lead identification, through the clinical phase.

Be the responsible DMPK/PD representative on multi-functional expert teams, contributing to the evaluation of new chemical entities (NCEs).

Identify and address key DMPK liabilities for new chemical series during the Lead Identification phase.

Design and execute eADME optimization strategies to mitigate safety risks and ensure adequate exposure in preclinical safety evaluations and clinical studies

Plan (in close collaboration with technology platform-owners), ADME, PK, and PK/PD studies, which are needed to select and characterize investigational new drugs

Integrate DMPK/PD, bioanalytical, and biotransformation data to address complex project challenges, enabling informed and timely decision-making.

Employ translational PK/PD principles, including basic modeling and simulation (e.g., PKPD, PBPK, and human dose/dose regimen prediction), to guide drug discovery and development activities.

Prepare scientific assessments of non-clinical DMPK information on development compounds suitable for internal program review and regulatory submissions

Expand scientific visibility and maintain effective interactions with internal and external collaborators

Who You Are

Education/Qualifications

A Ph.D. or equivalent degree in pharmaceutical sciences or other relevant bioscience discipline. Additional years of Post-doctoral and/or Industrial experience are a plus.

Ability to communicate confidently in English with colleagues and collaborators via teleconferences, presentations and written reports

Job Required Competencies

Expertise on DMPK project leader

In-depth experience with modern approaches in DMPK/PD used to support drug discovery projects (in vitro, in vivo, and computational tools)

Background in working closely with colleagues in chemistry, biology, in vivo DMPK and pharmacology

Knowledge of the drug development processes the context of pharmaceutical industry

DMPK/PD based experience and track record in the pharmaceutical industry is a plus

Hands-on experiences with PBPK, PK/PD and M&S techniques would be beneficial

Knowledge and familiarity with common DMPK assays and early DMPK compound screening strategies 

Strong interpersonal skills and team player

Leadership Competencies

preferable

Propose and evaluate innovative DMPK/PD approaches and develop new scientific strategies within the ADME/DMPK area.

Have a highly self-motivated and innovative mindset and guide development of new assays

Build open and honest collaborations with internal and external partners (for example global colleagues, CROs, universities, research institutes)

Good English communication and presentation skills.

Good organizational and multi-tasking abilities to ensure quality and timely delivery of the project deliverables

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer.