**Job title:** Senior Scientist, Retinal Degeneration **Location:** Cambridge, MA **About the job** Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. **Position Overview:** Sanofi is seeking a highly motivated translational scientist to spearhead preclinical drug discovery programs for blinding retinal diseases, including age-related macular degeneration and glaucoma. As a Senior Scientist in the Retinal Degeneration group within Ophthalmology Research, you will use innovative experimental approaches and advanced disease models to validate therapeutic strategies and discover promising drug candidates. The successful candidate will work collaboratively in matrixed, cross-functional teams to generate high-quality and comprehensive data packages to nominate and advance therapeutic candidates toward clinical development. This role presents an exciting opportunity to help shape the future of ophthalmology therapeutics and bring transformative vision-preserving treatments to patients around the world. We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started? **Main Responsibilities:** + Apply scientific expertise and judgement to initiate, design, direct, execute, analyze, and document research studies to translate new targets from discovery to therapeutic disease programs and preclinical development + Lead research projects in a matrixed team environment to achieve go/no-go decisions + Design and conduct in vitro and in vivo mechanism-of-action, proof-of-concept, and biomarker studies to validate targets and evaluate therapeutic strategies + Develop assays and collaborate cross-functionally to screen preclinical candidates of diverse modalities using target- and disease-relevant functional readouts + Design and conduct in vitro and in vivo studies to evaluate the pharmacology and efficacy of preclinical candidates + Contribute to interdisciplinary research programs in a highly collaborative manner across internal groups and with external partners. + Prepare high-quality analyses, interpretation, documentation, and presentations to support project milestones, publications, patent filings, and regulatory (IND/CTA) filings + Present project data packages at governance meetings + Communicate findings internally and externally through presentation and publication **About You** **Basic Qualifications:** + Earned Ph.D. or equivalent advanced degree in molecular biology, cellular biology, or related discipline PLUS at least 3 years research experience in biopharmaceutical or academic setting + Experience in ophthalmology research, ocular cell biology (e.g., RPE, RGC), age-related macular degeneration, glaucoma, retinal disease and degeneration, neurodegeneration, and/or neuroprotection + Experience in translational research or drug development + Comprehensive experience with molecular, cellular, and biochemical methods, assay development, and in vitro and in vivo disease models + Experience preparing high-quality documents including experimental protocols, SOPs, technical reports, and presentations + Track record of significant contribution to research projects and scientific publications **Preferred Qualifications:** + Experience in drug development for retinal diseases (glaucoma preferred) + Experience with cell-based and animal models of retinal disease and degeneration + Experience conducting in vivo pharmacology and/or biodistribution studies in rodents or NHPs + Experience drafting regulatory documents to support IND or CTA applications with agencies like the FDA and EMA + Experience managing studies at CROs + Experience analyzing data using computational approaches (e.g., R, Python) + Experience with assays for ocular disease processes, such as cell death, barrier function, metabolic and oxidative stress, lipid metabolism, tissue remodeling, and inflammatory signaling + Experience in high-throughput assay development + Experience using automated high-throughput screening platforms and robotics **Skills and competencies:** + Ability to work independently as well as part of cross-functional teams in a highly collaborative and matrixed environment + Ability to multi-task and adapt to rapidly changing priorities and deadlines + Excellent critical thinking, analytical, and problem-solving skills + Excellent written and oral communication skills, with the ability to communicate effectively in a multidisciplinary team + Strong interpersonal skills, with the ability to build excellent working relationships + Exceptional organizational and time-management skills, lab notebook practices, and attention to detail **Why Choose Us?** + Bring the miracles of science to life alongside a supportive, future-focused team.​​ + Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.​​ + Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.​​ + Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.​ Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. \#GD-SA ​ \#LI-SA \#LI-Onsite \#vhd **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! _US and Puerto Rico Residents Only_ Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. _North America Applicants Only_ The salary range for this position is: $100,500.00 - $145,166.66 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the LINK (https://benefits.sanofiusallwell.com/fleet/public/index/ba511bf8-5c32-4828-9861-ab985fffab90/?cid=sanofi) . Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/) Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)