**Why Mayo Clinic** Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans (https://jobs.mayoclinic.org/benefits/) – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic. **Benefits Highlights** + Medical: Multiple plan options. + Dental: Delta Dental or reimbursement account for flexible coverage. + Vision: Affordable plan with national network. + Pre-Tax Savings: HSA and FSAs for eligible expenses. + Retirement: Competitive retirement package to secure your future. **Responsibilities** Independently sets up and performs experiments and procedures in support of lab goals and grant commitments (e.g. assays, cell/tissue culture, animal studies, etc.). Contributes to the planning, design and modification of studies and experiments in the research lab setting. Monitors results, reports unusual outcomes and suggests modifications. Collects, enters, summarizes, and analyzes data. May oversee and assist with the training of residents, fellows and temporary lab personnel in lab techniques. Works with minimal supervision and performs assignments independently as discussed and approved by Principal Investigator. **Additional Information:** The Horbinski Lab is dedicated to advancing brain tumor research through innovative preclinical modeling of gliomas and meningiomas, as well as developing cutting-edge molecular biomarkers from both tissue and liquid biopsies. We are seeking a highly skilled and motivated Senior Research Technologist to join our team. Key Responsibilities The Senior Research Technologist will serve as a specialist in molecular biology, leading projects involving advanced genomic and epigenomic assays while also contributing expertise in animal models. This hybrid skillset will make the individual a key resource for bridging bench-based molecular work with preclinical modeling. + **Key Responsibilities** The Senior Research Technologist will serve as a **specialist in molecular biology** , leading projects involving advanced genomic and epigenomic assays while also contributing expertise in animal models. This hybrid skillset will make the individual a key resource for bridging **bench-based molecular work** with **preclinical modeling** . + **Molecular Biology Leadership** + Lead biomarker studies requiring advanced sequencing technologies. + Prepare sequencing libraries for whole genome, methylation, and RNA-based assays. + Drive adoption and optimization of emerging platforms, including **Nanopore sequencing** . + Ensure quality control and reproducibility across molecular experiments. + **Animal Model Support** + Apply hands-on experience with mice, including handling, injections, and monitoring for tumor xenograft studies. + Assist with in vivo experimental design and contribute to **IACUC protocol preparation** . + Collaborate with in vivo specialists to integrate animal studies with molecular analyses. + **Mentorship & Collaboration** + Train and supervise Research Technologists in both molecular and animal techniques. + Work closely with the Principal Research Technologist and PI to align molecular biology efforts with overall research goals. + Contribute to troubleshooting, data interpretation, and the development of new protocols. ***This is a limited tenure position that has been approved for one year that may have the possibility of turning into a regular position.** ***Visa sponsorship is not available for this position. This position is not eligible for F-1 OPT STEM extension.** **Qualifications** Requires bachelor's degree in biology, chemistry, or other relevant science with 4 years of research laboratory experience. Master's degree in biology, chemistry, or other relevant science preferred. **Additional Preferred Qualifications and Experience:** + Degree in molecular biology, genetics, cancer biology, or a related field. (Masters preferred) + Strong track record of hands-on experience in sequencing library preparation and other advanced molecular assays. + Working knowledge of animal models, including tumor xenografts, with a solid understanding of compliance requirements. + Proven ability to mentor junior staff and uphold high standards of accuracy and reproducibility. + Excellent problem-solving skills, adaptability, and collaborative mindset. **Exemption Status** Exempt **Compensation Detail** $66,123.20 - $99,236.80 / yr Education, experience and tenure may be considered along with internal equity when job offers are extended. **Benefits Eligible** Yes **Hours/Pay Period** 80 **Schedule Details** Monday - Friday (Standard Business Hours) **Weekend Schedule** As needed **International Assignment** No **Site Description** Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations) **Equal Opportunity** All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" (https://www.eeoc.gov/poster) . Mayo Clinic participates in E-Verify (https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf) and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization. **Recruiter** Matt Burdick **Equal opportunity** As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.