By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice (https://jobs.takeda.com/privacynotice) and Terms of Use (https://www.takeda.com/terms-and-conditions/) . I further attest that all information I submit in my employment application is true to the best of my knowledge. **Job Description** Takeda Lessines is looking for a **Senior MES Engineer** to lead and support our **Manufacturing Execution System (MES)** landscape, based on **Siemens Opcenter** . You will ensure robust shopfloor execution and electronic batch records, drive continuous improvement, and deliver MES **projects and enhancements** end-to-end—working in close partnership with **Manufacturing stakeholders** , **Quality** , and the **Automation team** . **ACCOUNTABILITIES** **Support & Operations** + Provide expert-level support for Siemens Opcenter: incident management, root cause analysis, problem management, and prevention of recurring issues. + Act as the primary MES point of contact for **Manufacturing stakeholders** : understand business needs, challenge and refine requirements, and translate them into scalable MES solutions. + Drive strong collaboration with the **Automation team** : coordinate troubleshooting across MES–SCADA/PLC or DCS layers, align on equipment connectivity and changes, and ensure seamless shopfloor execution. + Ensure GMP compliance and support audits/inspections: data integrity, audit trails, electronic records/signatures as applicable. + Maintain and improve documentation (SOPs, configuration specs, work instructions) and coach junior engineers and key users. + Participate to a “On Call” support level 2 **Projects & Delivery** + Lead MES **projects and enhancements** from initiation to Go Live: scoping, planning, stakeholder alignment, execution and lessons learned. + Facilitate workshops and requirements gathering; produce functional specifications and configuration/design documentation. + Manage end-to-end testing strategy and execution (risk-based), including **CSV deliverables** (traceability, test scripts/protocols, evidence, deviations). + Coordinate technical delivery with Automation, IT, Quality, system integrators. + Support integrations and data flows between MES and connected systems (e.g., ERP, historians, LIMS, SCADA/PLC, DCS layers), including troubleshooting and lifecycle management. + Identify opportunities to standardize, simplify, and increase reliability/performance of MES solutions **EDUCATION / EXPERIENCES** + Bachelor’s or Master’s degree (or equivalent) in Engineering, Automation, Computer Science, or related field. + Typically **5+ years** of experience in MES within a manufacturing environment (GMP-regulated experience strongly preferred). + Strong hands-on experience with **Siemens Opcenter** (configuration, troubleshooting, deployment/support). + Solid understanding of CSV in regulated environments (risk-based validation, traceability, test execution, controlled documentation). + Experience working with cross-functional stakeholders and delivering changes/projects in production environments. + Experience with Siemens Opcenter solutions integrated with PCS7 and Simatic Batch is a **strong asset** + Experience with OSI PI is a **strong asset** **Nice to have** + Experience with SQL, and/or reporting/analytics. + Knowledge of ISA-95, electronic batch records, recipe/workflow design, and data integrity (ALCOA+). + Vendor management / system integrator coordination experience. + Familiarity with broader shopfloor/OT stack (SCADA, historians, PLC concepts, DCS concepts). **Core Competencies / Skills / Leadership Behaviors** + **Proactive, motivated, and continuously learning** , staying curious about shopfloor processes and digital manufacturing. + **Team player** with strong collaboration habits. + **Excellent communication** : able to translate complex technical topics into clear messages for diverse audiences; confident in driving alignment. + **Positive, solution-oriented mindset** . + Ability to work in a structured, regulated environment with **strong attention to documentation, change control, and detail.** + Professional working proficiency in **English** ; **French** is highly valued for day-to-day collaboration in Lessines. + **Ability to prioritize multiple tasks** and work on multiple projects simultaneously **Locations** BEL - Lessines **Worker Type** Employee **Worker Sub-Type** Regular **Time Type** Full time