Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.
What You Will Achieve
As a Senior Associate Scientist, you will be at the center of our scientific vaccine operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a team leading the important role of generating viruses such as human parainfluenza virus (HPIV), human cytomegalovirus (HCMV), influenza viruses, and SARS-CoV-2 under BSL-2 and BSL-3 conditions. Primary responsibilities will include maintaining mammalian cell culture, optimizing virus propagations in cells to produce high titer stocks for vaccine efficacy research, performing virus characterization assays, and coordinating with teams across the site to ensure viral reagent needs are met. You will manage and update reagent inventories, plan and execute production of virus batches, and organize virus distributions to other groups within Pfizer to meet critical deadlines supporting vaccine research and development. Other responsibilities will include collaborating on data and information transfer between groups, development and integration of laboratory immunoassays, and supporting high throughput assay activities and testing for clinical and non-clinical research programs.
Your strong foundation in general scientific practice and its principles and concepts will help in meeting critical deadlines. You will be relied on as a technical contributor to assess the assigned tasks and make decisions that involve direct application of your knowledge. It is your hard work and focus that will make Pfizer ready to achieve new milestones and help patients across the globe.
How You Will Achieve It
Exercise key team effectiveness skills (e.g., commitment, feedback, consensus management) within the immediate work groupGrow and maintain different mammalian cell lines and perform virus infections to produce stocks supporting downstream assaysPerform virus titrations using methods such as TCID50, FFA, and plaque assayManage and maintain detailed virus and reagent inventoriesWrite, review, and update documents associated with virus production and functional bioassays, including standard operating procedures, test methods, and technical reportsObtain clinical isolates from external vendors and prepare reagents necessary to produce virus stocksCollaborate with colleagues in Pfizer Vaccines organization including early bioprocess, preclinical, and clinical development groupsPresent progress and results on viral production and processes to colleagues and managementCollect and analyze laboratory data to interpret results for troubleshooting, qualifications, and other laboratory projectsQualifications
Must-Have
BS degree in life sciences (e.g. biology, immunology, virology, microbiology) or related discipline with 3+ years of laboratory experience or MS degree in life sciences or related discipline with 1+ years of laboratory experienceExperience in a BSL-2 setting and aseptic techniquesExperience with mammalian cell cultureExperience with DNA/RNA extractions and qPCRAbility to multitask and carry out responsibilities independently as an influential team memberStrong attention to detail, good verbal and written communication skills, and the ability to collaborate and work in team environmentProficient computer skills including word processing, Excel, and PowerPointNice-to-Have
Background in virology, especially viruses causing illnesses in humans such as influenza viruses, SARS-CoV-2, HPIV, and HCMVBSL-3 experienceExperience with LIMS, PyMOL or UCSF Chimera, GraphPad Prism, Geneious or related softwareExperience analyzing gene sequences and mutationsExperience developing and troubleshooting cell-based and immunoassays such as neutralization and FFAExperience with instruments such as CTL ImmunoSpot, Softmax Pro, and QuantStudioPHYSICAL/MENTAL REQUIREMENTS
Ability to meet the standard requirements for a lab-based role and perform all typical lab related activities (lifting <20 pounds, frequent pipetting, long stretches on feet, etc)Ability to work with infectious agentsAbility to work while wearing a powered air purifying respirator (PAPR) for up to several hours at a time
Work Location Assignment: On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development