Scientist - Proteomics
Insight Global
Job Description
The Molecular Modalities Discovery group is seeking a highly motivated scientist with expertise in proteomics and informatics to support capability development in the mass spectrometry (MS)-omics space, with a particular focus on oligonucleotides and single-point mutations. This is a bench-focused role requiring hands-on experience in biological mass spectrometry workflows.
Key Responsibilities
Perform biological mass spectrometry workflows with a primary focus on proteomics.
Support small molecule discovery, including identification and progression of molecules that interact with drug targets.
Execute sample preparation steps, including:
Handling cryogenically preserved cells (not chemically fixed).
Buffer treatment for cell lysis and protein extraction.
Enrichment steps (e.g., amino precipitation).
Protein digestion and peptide processing.
Reconstitution and loading samples onto MS tips for automated analysis.
Learn and apply core workflows for MS-based proteomics.
Collaborate with partners for occasional live-cell handling.
Maintain accurate documentation and adhere to standard operating procedures.
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Skills and Requirements
Bachelor’s degree in Biology, Biochemistry, Chemistry, or related field (advanced degree preferred).
Hands-on experience with mass spectrometry in a biological context.
Strong understanding of proteomics workflows and sample preparation techniques.
Familiarity with informatics tools for MS data analysis is a plus.
Ability to work independently at the bench and troubleshoot technical challenges. Background in biology and handling biological materials.
Knowledge of oligonucleotide analysis and mutation detection.
Experience with automated MS workflows.
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