At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com **Job Function:** Discovery & Pre-Clinical/Clinical Development **Job Sub** **Function:** Chemical Research **Job Category:** Scientific/Technology **All Job Posting Locations:** San Diego, California, United States of America **Job Description:** **About Innovative Medicine** Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine **We are searching for the best talent for Scientist, Oligonucleotide Chemistry in San Diego, CA.** **Purpose:** RNA Therapeutics and Delivery is embedded in Cell & Genetic Medicines, an organization within Therapeutics Discovery, where we are committed to the development of high-quality drug candidates in the Oligonucleotide Therapeutics space working closely with Johnson & Johnson Innovative Medicines Therapeutic Areas (TA) discovery teams. Our mission requires critical thinking, a portfolio approach and deep scientific knowledge and expertise in several fields including oligonucleotide chemistry, bioconjugation chemistry, nanotechnology, cellular and molecular pharmacology and screening technologies coupled with an ability to work collaboratively with internal and external partners. This role offers growth opportunity within a dynamic and science driven organization. **You will be responsible for:** + Perform solid phase synthesis, purification, and analysis of oligonucleotides and bioconjugates in a team environment. + Support and trouble-shoot process development efforts for synthesis and characterization of oligonucleotides and their bioconjugates with higher throughput and automation. + In collaboration with the team, support oligonucleotide analytical efforts, optimization and design for de-risked, tissue-specific delivery. + Collect, document and evaluate experimental data and communicate scientific findings as verbal presentations and written reports. **Qualifications/Requirements:** + **Education:** Minimum of a B.S./B.A. with a minimum of 2-4 years of experience, performing progressively advanced duties at the Associate Scientist level, or the equivalent training/experience is required. Advanced degree is preferred. **Skills/Experience:** **Required:** + Hands-on experience with an emphasis on siRNA and/or ASO nucleic acid therapeutics synthesis and development. + Experience in siRNA synthesis, purification, and analytical characterization + Familiarity with the oligonucleotide delivery and drug discovery process + Critical thinking and scientific skills and a demonstrated ability to interpret and clearly communicate data + Strong team player with the ability to work effectively in a dynamic, matrixed team environment with diverse views + Ability to adapt to changing priorities and timelines **Preferred Qualifications:** + Experience in operating instruments and equipment including MerMade and Dr. Oligo synthesizers, as well as HPLC, LC-MS, and UV/Vis purification and characterization instrumentation. + Experience in increasing throughput and automation of oligonucleotide synthesis, characterization and documentation processes. + Knowledge and experience with delivery of oligonucleotides using bioconjugation strategies. + Knowledge of RNA biology and oligonucleotide screening technologies to facilitate effective team collaboration. The expected pay range for this position is $76,000 to $121,000 The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/ performance year. Bonuses are awarded at the Company’s discretion on an individual basis. + Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short and long-term disability, business accident insurance, and group legal insurance. + Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). + This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: + Vacation –120 hours per calendar year + Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year + Holiday pay, including Floating Holidays –13 days per calendar year + Work, Personal and Family Time - up to 40 hours per calendar year + Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child + Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year + Caregiver Leave – 80 hours in a 52-week rolling period10 days + Volunteer Leave – 32 hours per calendar year + Military Spouse Time-Off – 80 hours per calendar year For additional general information on company benefits, please go to: https://www.careers.jnj.com/employee-benefits This job posting is anticipated to close on December 11, 2025. The Company may however extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications. The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please contact us via https://www.jnj.com/contact-us/careers or contact AskGS to be directed to your accommodation resource. **Required Skills:** **Preferred Skills:** Analytical Reasoning, Chemistry, Data Analysis, Data Reporting, Drug Discovery Development, Execution Focus, Innovation, Interdisciplinary Work, Laboratory Experiments, Process Oriented, Quantitative Research, Research Ethics, Research Informatics, Scientific Evaluation, Scientific Research, Technical Writing, Technologically Savvy **The anticipated base pay range for this position is :** $76,000 to $121,000 Additional Description for Pay Transparency: Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation –120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year Holiday pay, including Floating Holidays –13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child Condolence Leave – 30 days for an immediate family member: 5 days for an extended family member Caregiver Leave – 10 days Volunteer Leave – 4 days Military Spouse Time-Off – 80 hours Additional information can be found through the link below. https://www.careers.jnj.com/employee-benefits