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In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

 The position is located in the Immune  and Cell Biology Department, within the Discovery unit  of pRED’s Large Molecules Research, where the discovery and development of next generation biotherapeutics is the primary focus. We closely collaborate with disease therapeutic areas and other functions to convert therapeutic hypotheses into innovative therapeutics.

In this environment, we are seeking an experienced Science and Matrix Leader (m/f/d) with a strong scientific background in immune and cell biology, and a specific focus on immunology, neuroscience and/or ophthalmology. The role requires significant industrial experience in drug discovery and development, encompassing the entire journey from target assessment to Entry into Human.  You will expertly lead cross-functional teams, contribute to portfolio projects, and drive the implementation of cutting-edge cell-based functional assays to discover and characterize large molecule-based therapeutics.

The opportunity 

You will lead and inspire highly engaged cross-functional matrix teams, foster effective collaboration, and cultivate trusting relationships with internal and external partners

You will be responsible for defining the cellular assay strategy and oversee data analysis for mode-of-action elucidations and in vitro lead selection in portfolio projects, with a particular focus on advanced, physiologically relevant human model systems

You will conceptually develop and set up novel functional cellular assays in the fields of Immunology, Oncology, Neuroscience and Ophthalmology, employing cutting-edge assay read-out technologies including flow cytometry and advanced fluorescence microscopy

Your Profile

Extensive industrial experience in large-molecule drug discovery, in particular leading cell-based assay development for therapeutic candidate selection in physiologically relevant model systems, including primary cells, iPSCs, organs-on-a-chip, and organoids

Solid experience in  assay readout technologies such as flow cytometry (including multiparameter and AMNIS technology), live-cell imaging (such as incucyte) and advanced fluorescence microscopy (confocal, super-resolution, FLIM, smFISH, and high-content imaging)

You have specific background in cell biology, immunology, neuroscience and or ophthalmology

A PhD in biology or other relevant fields  is the base of your knowledge

A keen interest in working with IT systems  for multiparameter data analysis in (semi-) automated workflows. Experience with  high-throughput screening platforms and large data analysis is an asset.

Demonstrated ability to lead and inspire highly engaged matrix teams, ideally as a project leader in drug discovery projects

Proven scientific expertise through documented contributions or publications in high impact journals in your scientific or technical field

You are resourceful and flexible in problem solving and in working in a collaborative and inclusive manner with strong oral and written communication skills   

Your final Scientific Career Ladder (SCL)-Title will be evaluated according to your individual scientific experience. 

Your application

Please keep it simple: a current resume that highlights your relevant experience and key achievements  + your latest certificates are all we need.

We are looking forward to your application!

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A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer.