**Why Mayo Clinic** Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans (https://jobs.mayoclinic.org/benefits/) – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic. **Benefits Highlights** + Medical: Multiple plan options. + Dental: Delta Dental or reimbursement account for flexible coverage. + Vision: Affordable plan with national network. + Pre-Tax Savings: HSA and FSAs for eligible expenses. + Retirement: Competitive retirement package to secure your future. **Responsibilities** The Nathan P. Staff Laboratory (https://www.mayo.edu/research/faculty/staff-nathan-p-m-d-ph-d/bio-00092632) is seeking a highly motivated Postdoctoral Fellow to investigate the cellular and molecular mechanisms of amyotrophic lateral sclerosis (ALS) using iPSC‑derived motor neuron models from patients with genetic forms of ALS. The fellow will design and execute experiments that combine advanced stem‑cell culture and differentiation, CRISPR‑based perturbations, high‑content imaging, electrophysiology, and transcriptomic/proteomic analyses to dissect pathways in axonal transport, RNA/protein homeostasis, and to identify and validate therapeutic targets. Responsibilities include quantitative data analysis, manuscript preparation, presentation of findings at national meetings, and collaborative work with clinicians, bioengineers, and computational scientists. A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic. **Qualifications** + Must have a Ph.D., M.D., or equivalent doctoral degree in neuroscience, cell biology, bioengineering, genetics, or related field. + Hands‑on expertise with human iPSC culture/differentiation strongly preferred. + Proficiency in one or more of CRISPR editing, electrophysiology, quantitative imaging, or -omics; and a strong publication record. + The ability to work as a team player within and outside of the program. + We offer a collaborative, well‑resourced environment with access to state‑of‑the‑art core facilities, competitive salary/benefits, and individualized career development. **Exemption Status** Exempt **Compensation Detail** $64,079 - $74,963 / year; Education, experience and tenure may be considered along with internal equity when job offers are extended. **Benefits Eligible** Yes **Schedule** Full Time **Hours/Pay Period** 80 **International Assignment** No **Site Description** Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations) **Equal Opportunity** All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" (https://www.eeoc.gov/poster) . Mayo Clinic participates in E-Verify (https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf) and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization. **Recruiter** Janell Mader **Equal opportunity** As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.