**Why Mayo Clinic** Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans (https://jobs.mayoclinic.org/benefits/) – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic. **Benefits Highlights** + Medical: Multiple plan options. + Dental: Delta Dental or reimbursement account for flexible coverage. + Vision: Affordable plan with national network. + Pre-Tax Savings: HSA and FSAs for eligible expenses. + Retirement: Competitive retirement package to secure your future. **Responsibilities** **Lab Overview:** The Lab of Dr. Margot Cousin at Mayo Clinic is seeking a highly motivated and experienced Research Technologist to join our dynamic research team. Our lab focuses on developing novel gene-targeted therapies for rare genetic diseases, including amyotrophic lateral sclerosis (ALS) and other rare genetic conditions. We employ cutting-edge cell-based models to understand the mechanisms of these diseases and explore innovative therapeutic approaches, including antisense oligonucleotides and other gene-targeted approaches and drug repurposing, with the goal of clinical translation. In collaboration with clinicians and researchers in the Department of Neurology and the Center for Individualized Medicine, the lab aims to identify individuals with rare and genetic disorders, match patients with personalized therapies, and advance these therapies in the lab. Through the N-of-1 Therapeutics Program, we leverage computational tools to interpret genetic data and develop targeted treatments. Our lab is committed to fostering a collaborative, team-oriented environment that supports professional growth. Research technologists receive hands-on training and mentorship from senior lab staff, with opportunities to expand technical skills, strengthen experimental troubleshooting capabilities, and gain exposure to translational research workflows and interdisciplinary collaboration. **Position Overview:** The Research Technologist will support ongoing research projects by performing laboratory experiments, maintaining accurate documentation, and contributing to data collection, analysis, manuscript preparation, and organization. This position works closely with lab members and collaborating teams, and performs duties with direction from the Principal Investigator and more senior laboratory staff. **Key Responsibilities:** **Laboratory Support & Experiment Execution:** + Perform experiments following established protocols and standard operating procedures (SOPs). + Support cell/tissue culture and routine molecular biology workflows (e.g., DNA/RNA isolation, PCR, gel electrophoresis, basic cloning support, Western blots). + Prepare reagents and buffers, maintain lab stocks, and support day-to-day laboratory operations to keep research activities running smoothly. **Data Collection, Documentation & Quality:** + Maintain clear, timely records of experimental procedures and results in lab notebooks and/or electronic systems. + Organize, summarize, and prepare datasets and figures for lab meetings, project updates, presentations, and manuscripts. + Communicate unexpected findings promptly and support troubleshooting efforts by repeating experiments, checking controls, and validating reagents when needed. **Collaboration & Teamwork:** + Coordinate work with lab members to meet project timelines and support shared lab goals. + Participate in lab meetings and communicate progress to supervisors and project leads. + Assist with onboarding/training of students or temporary staff on basic lab practices **Computational & Translational Project Support (as appropriate for experience):** + Assist with data organization, tracking, and analyses (e.g., spreadsheets, simple summaries, figure preparation). + Support collaborative projects involving genetic data interpretation workflows and help organize project materials and documentation. + Learn new tools and workflows as needed, with training and support. **Qualifications** Requires bachelor's degree in biology, chemistry, other relevant science, or an associates degree with 6 years of relevant laboratory experience. Must exhibit a solid understanding of lab techniques, equipment, and safety. Must have the ability to organize and carry out laboratory techniques independently and in a team setting. Experience with basic data analysis is required. This position requires demonstrated writing skills. Preferred Qualifications: + Education: Bachelor’s degree in molecular biology, Biology, Chemistry, Neuroscience, or a related scientific field preferred . (Master’s degree is a plus.) + Experience: 1–3 years of research experience in a laboratory setting (academic, clinical, or industry). Internship/research assistant experience may be considered. + Technical Skills: + Hands-on experience with some combination of: PCR, DNA/RNA isolation, basic cloning workflows, Western blotting, or cell culture. + Ability to follow detailed protocols, maintain accurate documentation, and manage assigned tasks reliably. + Familiarity with basic data tools (Excel/Google Sheets); experience with PRISM or similar software is a plus but not required. + Personal Attributes: + Strong attention to detail and good organizational habits. + Ability to manage multiple assigned tasks and meet deadlines in a team-based environment. + Willingness to learn new methods, ask questions, and seek guidance when needed. + Professional communication skills and a collaborative mindset. + Experience with molecular biology techniques. + Experience with iPSC or any stem cell culture, disease modeling, or assay development (helpful but not required). + Exposure to genetics/genomics concepts or an interest in rare disease research and translational science. + Prior experience working in a collaborative or clinically adjacent research environment. **Exemption Status** Nonexempt **Compensation Detail** Education, experience and tenure may be considered along with internal equity when job offers are extended.; $27.44-41.16/ hour **Benefits Eligible** Yes **Schedule** Full Time **Hours/Pay Period** 80 **Schedule Details** M-F 8-5 **Weekend Schedule** Potentially to take care of cells or animals **International Assignment** No **Site Description** Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations) **Equal Opportunity** All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" (https://www.eeoc.gov/poster) . Mayo Clinic participates in E-Verify (https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf) and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization. **Recruiter** Jill Squier **Equal opportunity** As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.