The Sahoo Lab at the Fralin Biomedical Research Institute studies the genetic and functional mechanisms that drive bone marrow failure, clonal hematopoiesis, and progression to MDS and AML. We integrate genomic and functional approaches on patient derived samples, iPSC and mouse disease models to uncover mechanisms and therapeutic vulnerabilities.

Current project areas include:
1. Germline predisposition to MDS and AML: mechanisms by which SAMD9L mutations cause hematopoietic failure and predispose to leukemogenesis
2. Chromosome 7 aneuploidy syndromes: modeling monosomy 7 associated bone marrow failure and its role in clonal selection
3. Clonal evolution and therapeutic vulnerabilities: using single cell sequencing to track clonal dynamics and to identify targets in high risk MDS and AML

We seek a full-time Research Tech to support our cellular, and in vivo studies. The role requires strong organizational skills, careful record keeping, and comfort working in a fast-paced research environment.

The key responsibilities will include if not limited to:
• Perform molecular biology workflows: DNA/RNA extraction, cloning, standard PCR genotyping, qPCR, gel electrophoresis.
• Support mouse studies: Main mouse colonies, perform genotyping, manage timed breeding, performing procedures (tail vein and intraperitoneal injections, routine blood collection) and sample collection (per approved protocols).
• Participate in laboratory projects involving the application of basic molecular biology techniques and mouse animal models.
• Open to learn new techniques, be inquisitive, collaborative and collegial
• Maintain lab inventories, data archiving, and uphold safety and compliance standards.

To apply: Provide a CV, a brief cover note describing relevant experience, and contact information for two to three references.