**Job Description** The Hemsley IBD research center and the Laboratory of Immunity and Tissue Regeneration at the Icahn School of Medicine at Mount Sinai seeks an outstanding and highly motivated Senior Translational Research Scientist to lead and coordinate translational human immunology research focused on immune-mediated inflammatory diseases. This position offers a unique opportunity to contribute to high-impact, patient-centered research at the interface of clinical investigation, laboratory science, and computational biology. The successful candidate will play a central role in the design, execution, and oversight of translational studies integrating clinical cohorts, biospecimen collection and processing, multimodal molecular profiling, and cross-disciplinary data analysis. The individual in this role will work closely with clinicians, clinical research coordinators, laboratory scientists, computational biologists, data engineers, and institutional core facilities to support rigorous and innovative studies involving blood- and tissue-based human biospecimens. This position will also involve interaction with external collaborators, including industry partners, and coordination of collaborative research studies across academic, clinical, and partner organizations. The role is ideally suited for a scientist who is excited by collaborative team science and motivated to advance biomarker discovery, translational insight, and therapeutic innovation in inflammatory disease. **Research Project Description** This position supports a portfolio of translational human immunology studies focused on the mechanisms, biomarkers, and therapeutic response pathways underlying immune-mediated inflammatory diseases. Projects involve the collection, processing, annotation, and analysis of human blood and tissue specimens from diverse clinical cohorts, together with the integration of clinical metadata and high-dimensional molecular profiling approaches. The work is designed to advance understanding of disease heterogeneity, identify clinically relevant biomarkers, and generate mechanistic insight that informs precision medicine strategies. **Technical Duties** The Senior Translational Research Scientist will oversee end-to-end study workflows linking clinical sample acquisition to downstream laboratory and computational analysis. Responsibilities include management of biospecimen processing pipelines, oversight of biobanking operations and sample inventories, development and maintenance of standard operating procedures, coordination of multimodal assays, and partnership with institutional immune monitoring and computational groups to support analytical pipeline development. The role also includes maintaining high standards of regulatory compliance for human studies, ensuring sample and data integrity, and coordinating collaborative study execution across internal and external stakeholders, including industry partners. **Goals and/or Outcomes of the Research Project** The overarching goal of this role is to establish and sustain a rigorous translational research infrastructure that enables mechanistic discovery in human inflammatory disease and accelerates progress toward clinical application. Expected outcomes include the generation of deeply annotated biospecimen and data resources, identification of biomarkers and pathways relevant to disease pathogenesis and therapeutic response, support for collaborative academic-industry research efforts, and dissemination of findings that may inform improved diagnostics and treatment strategies. **Qualifications** + Master’s or Ph.D in Biological Science or related field is strongly preferred. + 3+ years minimum research experience (may include academic studies) with Masters; 5 years with a Bachelor’s. Prior Faculty background preferred. Supervisory experience of lower-ranked research personnel is preferred. Preferred Skills + Experience in immune-mediated inflammatory disease, human immunology, translational biomarker studies, and cross-functional research coordination preferred. Experience managing collaborative projects involving academic, clinical, and industry partners is strongly preferred. Demonstrated organizational leadership and the ability to thrive in a highly collaborative translational research environment are highly desirable. **Preferred Qualifications** Experience in immune-mediated inflammatory disease, human immunology, translational biomarker studies, and cross-functional research coordination preferred. Experience managing collaborative projects involving academic, clinical, and industry partners is strongly preferred. Demonstrated organizational leadership and the ability to thrive in a highly collaborative translational research environment are highly desirable. **Responsibilities** + Design, implement, and oversee complex translational research studies across diverse clinical cohorts of immune-mediated inflammatory disease. + Coordinate the clinic-to-laboratory research pipeline, including biospecimen collection, processing, annotation, storage, and transfer, in collaboration with clinical research coordinators and clinical teams. + Organize, maintain, and oversee sample biobank inventories across multiple translational studies, ensuring accurate tracking, quality control, and compliance. + Determine sample analysis strategies using multimodal technologies and coordinate analytical pipeline development with Mount Sinai Human Immune Monitoring Center(s) and related institutional core facilities. + Coordinate data generation, analysis, and interpretation with computational biologists, data engineers, clinicians, and laboratory scientists. + Interact with external collaborators, including industry partners, to support collaborative translational research efforts and study execution. + Coordinate collaborative research studies across academic, clinical, and partner organizations, ensuring alignment of workflows, timelines, and deliverables. + Develop and maintain research standard operating procedures, biospecimen repositories, and data inventory workflows in conjunction with data engineering partners. + Organize seminars, scientific discussions, and collaborative meetings to support dissemination of findings and advancement of translational research goals. + Make decisions and recommendations with substantial impact on translational research activities, including study design, biospecimen strategy, analytical workflows, and operational implementation. + Maintain and support human study approvals, regulatory documentation, and compliance related to human subjects research. + Perform other related duties as assigned. **About Us** **Strength through Unity and Inclusion** The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. **About the Mount Sinai Health System:** Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. **Equal Opportunity Employer** The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization. **Compensation Statement** Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $87692 - $131538 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.