NY HELP No Agency People With Developmental Disabilities, Office for Title Research Scientist 1 - Genomic Medicine Laboratory EOA # 2025-43 Occupational Category I.T. Engineering, Sciences Salary Grade 18 Bargaining Unit PS&T - Professional, Scientific, and Technical (PEF) Salary Range From $70951 to $89138 Annually Employment Type Full-Time Appointment Type Permanent Jurisdictional Class Non-competitive Class Travel Percentage 0% Workweek Mon-Fri Hours Per Week 40 Workday From 8:30 AM To 5 PM Flextime allowed? No Mandatory overtime? No Compressed workweek allowed? No Telecommuting allowed? No County Richmond Street Address 1050 Forest Hill Road City Staten Island State NY Zip Code 10314 Duties Description The New York State Institute for Basic Research is seeking a qualified candidate to fill a full time Research Scientist I position in our Genomic Medicine Laboratory. The selected candidate will be working on projects which include studying a rare disease syndrome involving mutation in genes involved in amino-terminal acetylation of proteins. PRIMARY DUTIES AND RESPONSIBILITIES INCLUDE BUT NOT LIMITED TO:• This position for a Research Scientist will be focused on a rare genetic syndrome involving mutations in the genes NAA10 and NAA15, involved in the amino-terminal acetylation of proteins. • As part of our long-term focus on the mechanistic dissection of NTA, we will focus on detailed phenotyping of humans with mutations in the pathway, alongside a systems-level study of unique mouse models, including conditional alleles, using histologic and functional approaches to provide the first mechanistic insights into the role of NTA in cardiac development and mammalian physiology. • Work with lab staff in continuing our analysis of a newly identified (ELife 2021 Aug 6) enzyme in the pathway, which we propose compensates for and prevents embryonic lethality in mouse models with mutations in NAA10. There is an active collaboration on this project with Jackson Laboratory (JAX) in Maine, USA.• We will study the molecular biology and pathophysiology associated with NAA10- and NAA15-related disorders and the NTA pathway, as part of a sustained effort to understand the role of NTA in mammalian biology. • Projects being worked on include mouse studies and collaboration with New York Stem Cell Foundation (NYSCF), Manhattan, USA, on characterization of induced pluripotent stem cells, primary cells, and/or downstream assays. • Extraction of DNA from tissue specimens, using Qiagen column preparation procedure. • Setting up polymerase chain reaction (PCR) as part of routine genotyping of samples.• Running samples on a QiaXcel capillary electrophoresis machine and/or with agarose gels. Trouble-shooting of the instrument, with calls to Qiagen service center, may be needed.• Interpreting data and assigning genotypes.• Data entry, both manually and in an electronic spreadsheet.• Analysis of data with tabulation of results in Excel spreadsheets.• Communication with the project leader regarding prioritization of genotyping samples.• Occasional procurement of tissue samples may be required, which will involve handling mice. This can also include microdissection using the stereomicroscope.• Managing the mouse colony, with assistance from veterinary staff, including setting up matings and working with the PI and staff to characterize various phenotypes presenting in the mice.• There are ongoing mass spectrometry experiments, which the new scientist can assist with. This includes working with Dr. David Bolton, who manages the Xevo G2-XS QTof Waters instrument. PREFERRED QUALIFICATIONS: Master's degree preferred in a biological science with a strong molecular biology or biochemistry focus and one year experience. LinkedIn: https://www.linkedin.com/company/nys-office-for-people-with-developmental-disabilities/posts/?feedView=all#LI-DA1 Minimum Qualifications Non-Competitive: bachelor’s degree and two years of professional researchexperience in an appropriate field.Substitutions: master’s degree in an appropriate field may substitute for one year of experience, and Ph.D. in an appropriate field may substitute for an additional year of experience. Additional Comments • Please note that starting salary for this title reflects the Downstate adjustment. Posted Hiring Salary includes the sum of the statutory hiring rate for PS&T Grade 18 ($66,951) and Downstate adjustment ($4,000). Downstate adjustment is added to the job rate ($85,138).• If you are currently a New York State employee serving in a permanent competitive qualifying title and eligible for a transfer via Section 70.1 of the Civil Service Law, you may be appointed to this title as a permanent competitive employee.• The assignment of PS&T employees will be made in accordance with any agreed upon Memorandum of Understanding between PEF and the local DDSO regarding the posting of job vacancies.• Preference will be given to OPWDD employees impacted by closures. If you are being impacted by closure, please indicate this on your resume.• All OPWDD employees must be eligible and maintain eligibility for full and unconditional participation in the Medicare and Medicaid programs. Continued employment will depend on maintaining eligibility.• If you are employed by state government you may be able to receive loan forgiveness under the Public Service Loan Forgiveness Program (PSLF). The PSLF Program forgives the remaining balance on Direct Loans after 120 qualifying monthly payments have been made under a qualifying repayment plan while working full-time for a qualifying employer. For more information on PSLF, please visit www.studentAid.gov/publicservice.• Employees on long term leave can bid on positions but must be able to report to work within fourteen (14) days and be able to perform the essential functions of their positions with or without reasonable accommodation (RA). • If an employee or job applicant believes that they need a reasonable accommodation, they should contact the Reasonable Accommodation Unit at (518) 486-7222 or email accommodationrequests@opwdd.ny.gov to obtain information and RA forms.• Savings programs such as the U.S. Savings Bond and the College Savings Plan.• Voluntary pre-tax savings programs such as Health Care Spending Account and the Dependent Care Advantage Account offer employees options to pay for uncovered health care expenses or dependent care expenses.• Access to the Employee Assistance Program (EAP) an assessment and referral service that connects employees with local service providers and support services to address their personal needs.• Life insurance and Disability insurance.• The New York State Deferred Compensation Plan is a voluntary retirement plan that offers employees the option to invest a part of their salaries for retirement on a tax-deferred basis.• Paid Holidays and Leave: ° Thirteen (13) paid holidays each year. ° Thirteen (13) days of paid vacation leave initially. ° Five (5) days paid personal leave each year. ° Thirteen (13) days of paid sick leave each year (PEF/CSEA), which may carry over from year to year. ° Up to three (3) days professional leave each year to participate in professional development events.• Health Care Coverage:Employees and their eligible dependents can choose from a variety of affordable health insurance programs. Employees are provided family dental and vision plans at no extra cost.• Paid Parental Leave:Paid Parental Leave allows eligible employees to take up to 12 weeks of paid leave at full pay for each qualifying event. A qualifying event is defined as the birth of a child or placement of a child for adoption or foster care.• Retirement Program:Participate in The NYS Employees’ Retirement System (ERS), which is recognized as one of the best-managed and best-funded public retirement systems in the nation.• Professional Development and Education and Training:NYS offers training programs and tuition assistance to eligible employees to maintain and increase their professional skills and prepare them for promotional opportunities. For more information, please visit https://oer.ny.gov/training-and-professional-development.• Additionally, the Public Service Workshops Program (PSWP) offers certain professional training opportunities for PEF represented and M/C designated employees that may grant continuing education credits towards maintaining professional licensure. For more information, please visit https://oer.ny.gov/public-service-workshops-program-pswp.• OPWDD is an Equal Opportunity/Affirmative Action employer dedicated to creating and sustaining a culture of inclusion. We believe that we are most effective in managing and improving our service system with a diverse team of employees. With such a large workforce, we rely on the collective individual differences, life experiences, knowledge, self-expression, ideas and talent that our employees bring to their work. This speaks to our culture and is a key part of our successes. As we continuously recruit people for our team, we welcome the unique contributions that applicants bring in terms of their education, culture, ethnicity, race, sex, gender identity and expression, nation of origin, age, languages spoken, veteran’s status, color, religion, disability, sexual orientation and beliefs.• Please note that starting salary for this title reflects the Downstate adjustment. Posted Hiring Salary includes the sum of the statutory hiring rate for PS&T Grade 16 ($59,994) and Downstate adjustment ($4,000). Downstate adjustment is added to the job rate ($76,359). • The assignment of PS&T employees will be made in accordance with any agreed upon Memorandum of Understanding between PEF and the local DDSO regarding the posting of job vacancies. • Preference will be given to OPWDD employees impacted by closures. If you are being impacted by closure, please indicate this on your resume. • All OPWDD employees must be eligible and maintain eligibility for full and unconditional participation in the Medicare and Medicaid programs. Continued employment will depend on maintaining eligibility. • If you are employed by state government you may be able to receive loan forgiveness under the Public Service Loan Forgiveness Program (PSLF). The PSLF Program forgives the remaining balance on Direct Loans after 120 qualifying monthly payments have been made under a qualifying repayment plan while working full-time for a qualifying employer. For more information on PSLF, please visit www.studentAid.gov/publicservice. • Employees on long term leave can bid on positions but must be able to report to work within fourteen (14) days and be able to perform the essential functions of their positions with or without reasonable accommodation (RA). • If an employee or job applicant believes that they need a reasonable accommodation, they should contact the Reasonable Accommodation Unit at (518) 486-7222 or email accommodationrequests@opwdd.ny.gov to obtain information and RA forms. • Savings programs such as the U.S. Savings Bond and the College Savings Plan. • Voluntary pre-tax savings programs such as Health Care Spending Account and the Dependent Care Advantage Account offer employees options to pay for uncovered health care expenses or dependent care expenses. • Access to the Employee Assistance Program (EAP) an assessment and referral service that connects employees with local service providers and support services to address their personal needs. • Life insurance and Disability insurance. • The New York State Deferred Compensation Plan is a voluntary retirement plan that offers employees the option to invest a part of their salaries for retirement on a tax-deferred basis. • Paid Holidays and Leave: ° Thirteen (13) paid holidays each year. ° Thirteen (13) days of paid vacation leave initially. ° Five (5) days paid personal leave each year. ° Thirteen (13) days of paid sick leave each year (PEF/CSEA), which may carry over from year to year. ° Up to three (3) days professional leave each year to participate in professional development events. • Health Care Coverage: Employees and their eligible dependents can choose from a variety of affordable health insurance programs. Employees are provided family dental and vision plans at no extra cost. • Paid Parental Leave: Paid Parental Leave allows eligible employees to take up to 12 weeks of paid leave at full pay for each qualifying event. A qualifying event is defined as the birth of a child or placement of a child for adoption or foster care. • Retirement Program: Participate in The NYS Employees’ Retirement System (ERS), which is recognized as one of the best-managed and best-funded public retirement systems in the nation. • Professional Development and Education and Training: NYS offers training programs and tuition assistance to eligible employees to maintain and increase their professional skills and prepare them for promotional opportunities. For more information, please visit https://oer.ny.gov/training-and-professional-development. • Additionally, the Public Service Workshops Program (PSWP) offers certain professional training opportunities for PEF represented and M/C designated employees that may grant continuing education credits towards maintaining professional licensure. For more information, please visit https://oer.ny.gov/public-service-workshops-program-pswp. • OPWDD is an Equal Opportunity/Affirmative Action employer dedicated to creating and sustaining a culture of inclusion. We believe that we are most effective in managing and improving our service system with a diverse team of employees. With such a large workforce, we rely on the collective individual differences, life experiences, knowledge, self-expression, ideas and talent that our employees bring to their work. This speaks to our culture and is a key part of our successes. As we continuously recruit people for our team, we welcome the unique contributions that applicants bring in terms of their education, culture, ethnicity, race, sex, gender identity and expression, nation of origin, age, languages spoken, veteran’s status, color, religion, disability, sexual orientation and beliefs.***All people with disabilities are encouraged to apply.*** Some positions may require additional credentials or a background check to verify your identity. Name Staten Island DDSO Human Resources Office Telephone 7189835433 Fax 7189835216 Email Address StatenIsland.Careers@opwdd.ny.gov Address Street Staten Island DDSO Human Resources 1150 Forest Hill Road City Staten Island State NY Zip Code 10314 Notes on Applying Please email your resume and cover letter to StatenIsland.Careers@opwdd.ny.gov and reference vacancy ID number and EOA # 2025-43 in your email.