RESEARCH INVESTIGATOR Apply Now **How to Apply** A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position. **Job Summary** Note: This is a one-year term-limited appointment. The laboratory of Jiandie Lin at the Life Sciences Institute is looking for a Research Investigator to lead research projects to investigate 1) the cellular and molecular mechanism of metabolic diseases development, focusing on hepatocyte function and metabolic dysfunction-associated steatohepatitis (MASH) and 2) whether and how hepatocyte senescence drives MASH progression. These studies will require considerable expertise in metabolic biology and pathophysiology, research experiences in omics-platforms (e.g. single-cell/single-nucleus transcriptomics and proteomics) and cellular and molecular biology techniques, including immunofluorescent staining, confocal microscopy, real-time quantitative PCR, cloning, protein analyses and functional assays usingin vitrocellular andin vivoanimal models. You should have large-scale data analysis experience analyzing single-cell/single-nucleus RNA sequencing datasets, data interpretation and visualization and will be expected to write grant applications and present your research work in scientific conferences within and outside the University. In addition to planning and performing experiments, you will oversee research performed by students and research technicians and will report directly to Dr. Lin and work full-time on-site. **Mission Statement** Our mission at theLife Sciences Institute (https://www.lsi.umich.edu/) is to promote the understanding of the fundamental processes of life, and to pioneer new ideas to improve human health. For more information on the Lin laboratory: https://www.lsi.umich.edu/science/our-labs/lin-lab **Responsibilities*** Experimental responsibilities will include: + Maintain and manage genetically modified mouse colonies + Designin vivoexperiments to study regulatory mechanisms regarding the development of metabolic diseases + Design experiments using primary hepatocytes and hepatoma cell lines to study the regulatory signal pathways + Using omics-platforms to investigate the cellular and molecular mechanisms controlling the development of metabolic diseases + Analyze and interpret omics-based datasets + Perform quantitative analyses and communicate findings through reports and summaries + Solve experimental problems that arise in any of the responsibilities Non-experimental responsibilities will include: + Provide consultation and advice to laboratory members in areas of expertise + Write grants as a junior faculty + Assist the PI in preparing manuscripts and grants + Mentor the research work of junior trainees in the lab including graduate (master and doctoral) and undergraduate students + Present research work at scientific platforms within and outside the University + Follow laboratory best practices for safety and quality **Required Qualifications*** + Ph.D. in molecular biology, cell biology, biochemistry, or related discipline + Minimum three years of postdoctoral research experience + Minimum five years experience in cell and molecular biology techniques + Minimum five years experience in managing genetically modified mouse colony + Minimum three years experience in large-scale data analysis using bioinformatic tools + Proficiency in at least one programming language (e.g., Python, R, Shell) + Minimum three years experience mentoring students and research staff + Strong publication and scientific presentation record + Prior experience working in a collaborative environment **Modes of Work** Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about thework modes (https://hr.umich.edu/working-u-m/my-employment/ways-we-work-resource-center/ways-we-work-implementation-group/modes-work) . **Additional Information** **Benefits at the University of Michigan:** In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family, and plan for a secure future. Benefits include: + Generous time off + A retirement plan that provides two-for-one matching contributions + Many choices for comprehensive health insurance + Dental, Vision, and Legal Insurance + Life insurance + Long-term disability coverage + Flexible spending accounts for healthcare and dependent care expenses + Maternity and Parental Leave **Background Screening** The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act. **Application Deadline** All applications for this position must be received by 11:59p, Wednesday, October 1st. **U-M EEO Statement** The University of Michigan is an equal employment opportunity employer. **Job Detail** **Job Opening ID** 269007 **Working Title** RESEARCH INVESTIGATOR **Job Title** RESEARCH INVESTIGATOR **Work Location** Ann Arbor Campus Ann Arbor, MI **Modes of Work** Onsite **Full/Part Time** Full-Time **Regular/Temporary** Regular **FLSA Status** Exempt **Organizational Group** Life Sciences Inst **Department** Life Sciences Institute-Admin **Posting Begin/End Date** 9/24/2025 - 10/01/2025 **Salary** $70,344.00 **Career Interest** Primary Apply Now