**Why Mayo Clinic** Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans (https://jobs.mayoclinic.org/benefits/) – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic. **Benefits Highlights** + Medical: Multiple plan options. + Dental: Delta Dental or reimbursement account for flexible coverage. + Vision: Affordable plan with national network. + Pre-Tax Savings: HSA and FSAs for eligible expenses. + Retirement: Competitive retirement package to secure your future. **Responsibilities** The Gubatan Lab at Mayo Clinic Florida is seeking a postdoctoral research fellow to support a basic and translational research program in inflammatory bowel disease (IBD). The lab focuses on mechanisms of IBD pathogenesis, therapy resistance, and host immune–microbiome interactions using patient‑derived samples and established mouse models. **Research Responsibilities** The ideal candidate is a highly motivated scientist with expertise in immunology, bioinformatics, systems biology, or related disciplines, and experience in multi‑omics and translational research. Ongoing projects include: Spatial transcriptomics to investigate mechanisms of therapy failure in ulcerative colitis (JAK inhibitors) and small‑bowel Crohn’s disease (anti‑IL23 therapies). Peripheral blood scRNA‑seq, immune repertoire (TCR/BCR) sequencing, and machine learning to classify IBD and predict therapeutic response. Fibroblast–immune cell interactions in IBD. Regulation of IgA/IgG binding to gut microbiota. CX3CR1⁺ regulatory B cells and host–microbiome interactions. The fellow will apply single‑cell and spatial transcriptomics, shotgun metagenomics, IgA/IgG‑Seq, immune repertoire profiling, computational methods, cell culture, and mouse models. Responsibilities include presenting data, preparing manuscripts, and supporting grant submissions. Leadership and mentoring experience is beneficial. **Technical Skills** Preferred qualifications include proficiency in: Molecular biology (DNA/RNA isolation, qPCR, western blot, ELISA) Immunology techniques (flow cytometry, cell isolation, immunohistochemistry) Cell culture and co‑culture systems Mouse handling (genotyping, injections, drug administration, tissue harvesting) R and/or Python for bioinformatic analysis (transcriptomics, metagenomics, etc.) Microbiology experience is a plus **Supervisory Responsibilities** Mentor laboratory technicians, visiting scholars, and trainees in experimental design and data analysis. **Qualifications** Ph.D. or M.D./Ph.D. in Immunology, Biochemistry, Molecular/Cell Biology, Microbiology, Bioinformatics, Systems Biology, or a related field. Prior postdoctoral experience is helpful but not required. Strong background in multi‑omics is highly preferred. Excellent analytical, written, and verbal communication skills are required. Preferred qualifications include proficiency in: Molecular biology (DNA/RNA isolation, qPCR, western blot, ELISA) Immunology techniques (flow cytometry, cell isolation, immunohistochemistry) Cell culture and co‑culture systems Mouse handling (genotyping, injections, drug administration, tissue harvesting) R and/or Python for bioinformatic analysis (transcriptomics, metagenomics, etc.) Microbiology experience is a plus Application Instructions Interested candidates should submit a CV or NIH Biosketch and reference contact information or support letters from previous research mentors to Dr. John Gubatan at gubatan.johnmark@mayo.edu **Exemption Status** Exempt **Compensation Detail** $64,079 - $74,963 / year.; Education, experience and tenure may be considered along with internal equity when job offers are extended. **Benefits Eligible** Yes **Schedule** Full Time **Hours/Pay Period** 80 **Schedule Details** Varies **Weekend Schedule** Varies **International Assignment** No **Site Description** Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations) **Equal Opportunity** All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" (https://www.eeoc.gov/poster) . Mayo Clinic participates in E-Verify (https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf) and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization. **Recruiter** Amy Hoffman **Equal opportunity** As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.