**Why Mayo Clinic** Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans (https://jobs.mayoclinic.org/benefits/) – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic. **Benefits Highlights** + Medical: Multiple plan options. + Dental: Delta Dental or reimbursement account for flexible coverage. + Vision: Affordable plan with national network. + Pre-Tax Savings: HSA and FSAs for eligible expenses. + Retirement: Competitive retirement package to secure your future. **Responsibilities** **Postdoctoral Research Fellow - Translational Mucosal Immunology** **Primary Focus** Lead bench-based translational studies in the Kattah Lab (Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN) using patient intestinal biopsies and blood to dissect mechanisms of inflammatory bowel disease, CAR-T enteritis, and ICI colitis. Integrate single-cell/spatial multi-omics with experimental validation in human/mouse intestinal organoids and co-culture systems. **Key Responsibilities & Activities** Process patient biopsies/PBMCs, generate single-cell datasets (scRNA/CITE-seq), and identify testable pathways. Validate targets in tissue using immunofluorescence/spatial transcriptomics and in vitro using organoid-immune and organoid-stromal co-cultures. Perform CRISPR-Cas9 perturbations and functional epithelial assays (barrier integrity, viability, cytokine readouts), and imaging/flow cytometry. Maintain rigorous records, QC, and SOP adherence for human biospecimens. Analyze/interpret data with basic scripting skills (R/Python) and collaborate closely with computational partners. Write manuscripts, prepare figures, and present at lab/departmental meetings and national/international conferences Help mentor students/technicians. (~70% wet-lab experimentation, ~20% data analysis/interpretation, ~10% writing/mentoring.) **Qualifications** PhD in Immunology, Molecular/Cell Biology, Cancer Biology, Developmental Biology, Genetics/Genomics, Biochemistry, Microbiology, Pharmacology, Bioengineering/Biomedical Engineering, Neuroscience, or closely related field. Substantial wet-lab experience: sterile cell culture, flow cytometry, mouse models of disease. Strong communication skills and at least one 1 peer-reviewed publication. **Preferred qualifications** Experience with intestinal organoids Hands-on CRISPR editing/perturbation screens, including assay development and troubleshooting. Familiarity with single-cell/spatial pipelines and basic informatics (R or Python). **Exemption Status** Exempt **Compensation Detail** $64,079 - $74,963 / year; Education, experience and tenure may be considered along with internal equity when job offers are extended. **Benefits Eligible** Yes **Schedule** Full Time **Hours/Pay Period** 80 **International Assignment** No **Site Description** Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations) **Equal Opportunity** All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" (https://www.eeoc.gov/poster) . Mayo Clinic participates in E-Verify (https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf) and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization. **Recruiter** Kara Schott **Equal opportunity** As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.