**The Position** **The Opportunity** At Spark Therapeutics, the downstream process development (DSPD) team is seeking a highly motivated associate scientist/scientist with relevant industry experience to join the team. The successful candidate will participate in multiple downstream process development programs in Roche’s innovative pipeline. **What You’ll Do** ● Execute lab experiments according to predefined experimental design and protocols. ● Support the maintenance of essential equipment and critical raw materials to ensure smooth laboratory operations. ● Maintain comprehensive and accurate documentation with a high level of detail. Close out experiments in a timely manner while preparing and submitting well-written development reports. ● Collaborate with team members to ensure the DSP laboratories are maintained in a professional and organized working environment. ● Contribute to the troubleshooting, optimization, and scale-up of downstream processes to meet project objectives. **Who You Are** PhD in biochemistry, chemistry, chemical engineering, bioengineering, or related area with 0-3 years of relevant industry experience. Master/Bachelor in biochemistry, chemistry, chemical engineering, bioengineering, or related area with 3-7 years of relevant industry experience. ● Knowledge of downstream process development of the biologics, such as viral vectors, monoclonal antibodies, vaccines, and therapeutic recombinant proteins in the biopharma industry ● Hands-on experience with operating chromatography and filtration systems ● Working knowledge and skills for viral vector or vaccine purification is a plus. ● Working knowledge and skills for lipid nanoparticle (LNP) production is a plus ● Working knowledge of analytical techniques for in process testing or product characterization is a plus ● In-depth understanding in at least one of the following aspects is a plus: Chromatography, Tangential Flow Filtration (TFF) and T-mix operations. **Complexity and Problem Solving** ● Perform experiments with moderate complexity. ● Detail oriented data recording and analysis. ● Be able to identify issues and problems proactively, suggest solutions and solicit group members inputs and feedbacks Internal and External Contacts **Other Job Requirements** ● Must be able to lift 25 pounds ● Must be flexible with work schedule and available to work extended hours if needed ● Must be able to wear all Personal Protective Equipment as required ● Must be able to stand for long periods **Relocation funding is not available for this role.** The expected salary range for this position based on the primary location of Philadelphia, PA is $91,000 - $169,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits (https://roche.ehr.com/default.ashx?CLASSNAME=splash) Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (https://docs.google.com/forms/d/e/1FAIpQLSdZWlsbfQOvFVIQgHE\_iDzWUTlhZvj6FytIzjS7xq6IGh1H5g/viewform) .