**Job Description** **Details of Research Project** : Title: Hippo pathway signaling in podocyte injury and glomerular disease Our lab has identified Hippo pathway upstream regulator KIBRA (Kidney BRAin) protein as a novel mediator of podocyte injury via inhibition of downstream pro-survival transcriptional co-activator YAP. Our previous work has demonstrated that upregulated KIBRA podocyte expression increases susceptibility to a murine model of FSGS and also that _WWC1_ (the gene encoding KIBRA) is a risk gene for glomerular disease progression in human podocytopathies. Preliminary data suggests that increased KIBRA/Hippo pathway activation enhances podocyte injury in a diabetic milieu. We aim to test this hypothesis and the potential therapeutic role of small molecule Hippo mediators using complementary models including immortalized podocytes, hIPSC-derived podocytes and kidney organoids, diabetic rodent models, and banked human kidney tissue/biosamples. Other aims of this work include defining positive and negative regulators of _WWC1/_ KIBRA expression and downstream consequences of increased Hippo pathway activity on key podocyte cytostructural elements, namely the actin cytoskeleton and focal adhesion complexes. **Qualifications** **Educational and Other Requirements for the Position** : Bachelors and Masters or Doctoral Degree **Experience Required** : at least 2 years in lab environment **Goals/Outcomes of the Research Project** : This work is anticipated to lead to multiple publications and to support future grant submissions in order to expand this research program **Responsibilities** **Technical Duties** : (include any protocols): + Leading laboratory projects + Preparing figures for manuscripts and writing Results sections of manuscripts + Training junior lab members/students + Aseptic cell culture techniques + Protein extraction, western blotting + RNA extraction, PCR/qPCR + Immunofluorescence/immunohistochemistry staining + Confocal and TIRF microscopy + Rodent animal handling, urine collection, and intraperitoneal/retroorbital injection **About Us** **Strength through Unity and Inclusion** The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. 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We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization. **Compensation Statement** Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.