At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness this transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide.
 

You will play a pivotal role in supporting, applying, and advancing the next generation of large molecule generative machine learning models for drug discovery. We seek an individual who is not only passionate about teamwork and technical problem-solving but also has a proven track record of delivering innovative solutions in machine learning and antibody engineering. Your responsibilities will include data preparation and cleaning, deploying both internal and external discriminative and generative models, and closely collaborating and communicating with colleagues  s across Roche’s antibody engineering portfolio Roche’s antibody engineering portfolio.

Your Responsibility

Apply novel Computational Biology/Machine Learning methods to answer challenging research questions in LMDD

Work with biological data from heterogeneous sources

Collaborate closely with cross-functional teams across Roche to solve complex problems, including developing models to predict antigen-antibody affinity and developability properties, and to perform generative design of de novo macromolecules

Manage collaborations between experimental biologists and computational colleagues and bioinformaticians across departments in the organization.

Contribute to and drive publications and present scientific findings at internal/external venues.

Who you are

PhD degree in Computational Biology, Structural Biology, Computer Science ,or related disciplines, or an MS degree in the above disciplines with 3+ years of industry research experience.

Demonstrated experience with Python and deep learning libraries such as Pytorch and/or TensorFlow and/or JAX

Demonstrated experience in structural modelling, protein and antibody design

Demonstrated experience in diffusion models, LLMs, and latest state of the art ML methods

Demonstrated research experience, including at least one first-author publication or equivalent.

Publication record and experience contributing to research communities, including conferences like NeurIPS, ICML, ICLR, CVPR, ACL, etc.

Strong communication and collaboration skills. 

Additional desired qualifications:

Experience working with data from biology, immunology, or related disciplines, and experience in drug discovery projects

Public portfolio of computational projects (available on e.g. GitHub)

#ComputationCoE

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer.