**Job Description: Senior Associate Scientist - In Vivo Pharmacology** **Location:** Bothell, WA **Organization:** Oncology Research Unit (ORU) - In Vivo Pharmacology **Position Type:** Full-time **Career Level:** Senior Associate Scientist (Non-PhD track) **Position Summary** The Oncology Research Unit (ORU) is seeking a **hands-on, execution focused Senior Associate Scientist** to join the **In Vivo Pharmacology** group at the Bothell, WA site. This role is primarily responsible for the **execution of in vivo experiments** supporting preclinical oncology drug discovery programs, including **antibody drug conjugates (ADCs)** . The Senior Associate Scientist will perform **in vivo efficacy, PK/PD, and mechanistic studies** , along with **in vitro aseptic mammalian tissue culture** , generating high quality data that supports project progression. This position is highly lab based and operates within a collaborative research environment where technical rigor, reproducibility, and compliance are critical. **Key Responsibilities** **In Vivo Study Execution (Primary Focus)** + **Execute in vivo pharmacology studies** to assess anti-tumor efficacy, dose response, PK/PD relationships, and mechanism of action. + Perform routine and advanced **in vivo dosing techniques** (IV, IP, SC, PO) in tumor bearing mice. + Conduct tumor measurements, clinical observations, necropsy support, and biological sample collection (blood, plasma, tumors, tissues). + Utilize a variety of oncology models, including **CDX, PDX, syngeneic, GEMM, and humanized mouse models** . **Aseptic Technique & Mammalian Tissue Culture** + Perform **aseptic mammalian tissue culture** to support in vivo studies, including cell expansion, maintenance, and preparation for tumor implantation. + Generate high-quality cell preparations for **in vivo tumor model establishment** . + Apply strict aseptic technique to ensure sterility, reproducibility, and experimental integrity. + Maintain cell culture documentation, inventory, and quality control records. **Data Handling & Team Communication** + Document and maintain accurate and compliant electronic laboratory notebooks and experimental records in accordance with **IACUC regulations and Pfizer standards** . + Compile, organize, and summarize experimental data for internal reports and presentations. + Communicate results clearly during project and group meetings. + Support multiple concurrent studies by managing day-to-day experimental execution and timelines. **Qualifications** **Required** + **BS** with 3+ years of relevant experience **or MS** with 1+ years of relevant experience in **in vivo pharmacology, oncology, tumor biology, or a related discipline** . + Demonstrated **hands-on experience with murine in vivo tumor models** . + Experience performing **in vivo dosing, tumor measurements, necropsy support, and sample collection** . + Strong attention to detail, documentation quality, and experimental reproducibility. **Preferred** + Experience supporting **oncology drug discovery programs** , particularly ADCs or immuno-oncology agents. + Proven proficiency in **aseptic technique and mammalian tissue culture** . + Familiarity with basic **PK/PD concepts** . + Experience working in a **high-throughput, multi-project laboratory environment** . + Experience training or mentoring junior research staff on laboratory techniques. **Role Emphasis (Execution-Focused)** + Majority of time spent **performing laboratory-based experimental work** + Limited scope beyond **study execution and data generation** + Emphasis on **technical excellence, consistency, and high-quality data delivery** + Works under direction of senior staff members who provide study objectives and oversight **PHYSICAL/MENTAL REQUIREMENTS** Requires ability to perform in vivo laboratory work including sitting, standing, lifting (up to ~25 lbs), manual handling of animals and equipment, wearing PPE, and working in regulated animal facility environments. Role requires attention to detail, adherence to safety and animal welfare standards, and flexibility to support study-driven schedules. Work Location Assignment: On Premise The annual base salary for this position ranges from $68,600.00 to $114,300.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future. **Sunshine Act** Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. **EEO & Employment Eligibility** Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. Research and Development