Job Title: Immunology Scientist Location: Cambridge, MA Hours/Schedule: Monday–Friday, 8 am to 5 pm Type: Contract (6 months) Overview The Scientist will join the Systems Immunology Lab within an Inflammation & Immunology research unit to generate large-scale single-cell perturbational datasets. This role focuses on functional genomics and single-cell transcriptomics, working hands-on at the bench and collaborating closely with a small, multidisciplinary research team. Responsibilities + Generate custom lentiviral libraries and maintain large-scale cell cultures. + Produce edited cell pools using lentiviral transduction and arrayed electroporation. + Develop, optimize, and customize protocols to support diverse cell lines and cell types at scale. + Generate single-cell datasets using commercial workflows, including 10x Genomics platforms. + Perform standard molecular biology and cell-based assays to support functional genomics studies. + Collaborate with multidisciplinary experimental teams on a per-project basis. + Document experimental procedures, results, and observations in accordance with laboratory standards. Qualifications Must Have + Bachelor’s or Master’s degree in Biology, Immunology, or a related scientific field. + 3+ years of hands-on laboratory experience. + Strong experience with cell culture techniques, including primary immune cell handling, isolation, and in vitro stimulation. + Experience maintaining cell lines and working with large-scale cultures. + Hands-on experience with molecular biology techniques, including lentiviral infection, qPCR, western blotting, and flow cytometry. + Ability to perform routine bench work, including pipetting and lifting items up to approximately 10 lbs. Nice to Have + Direct experience with pooled cell screening approaches such as CRISPRi, CRISPRa, or other in vitro gene-editing methods. + Experience generating or working with single-cell transcriptomics data. Benefits System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan. Ref: #558-Scientific System One, and its subsidiaries including Joulé, ALTA IT Services, CM Access, TPGS, and MOUNTAIN, LTD., are leaders in delivering workforce solutions and integrated services across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible full-time employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan. System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.