Use Your Power for Purpose

The key purpose of this position is to influence the early candidate, organic small molecule substrate from a physical chemical, drug delivery and bioperformance perspective through close collaboration with partners on the Research project teams and in Pharmaceutical Science.  You will need to act as a resident pharmaceutical science subject matter expert to inform, educate and influence Research teams in finding NCEs with desirable drug delivery and bioperformance properties.  This role will include assessment of in silico, in vitro and in vivo data as well as design of stage appropriate formulations for preclinical studies.  An awareness of later stage, oral solid development needs, as well as an understanding of the disease state and patient populations, will help to enable the definition of the required molecular design elements.

What You Will Achieve

In this role, you will:

Evaluate the physicochemical properties of potential small molecule drug candidates to inform a drug product formulation strategy and developability risk assessment 

Closely collaborate with Drug Discovery partners to evaluate molecular attributes relevant to drug delivery and influence team strategies

Apply first principles understanding of thermodynamics and kinetic processes to dissolution and precipitation of drugs in biorelevant conditions and physical and chemical stability in the solid state.   

Design and develop fit for purpose preclinical formulations (traditional and enabling) to enable robust candidate selection and progression

Assess and clearly communicate drug delivery and performance risks (using in silico, in vitro and in vivo data as well as sound scientific principles)

Maintain an awareness of and contribute to scientific literature; actively apply new concepts as appropriate

Conduct novel research and present significant findings via internal and external presentations or publications

Here Is What You Need (Minimum Requirements)

Recent PhD with 0-3 year post-doctoral experience, MS with 7+ years experience, or BS with 8+ years' experience in Chemistry, Engineering, Physical Chemistry, Physics, Physical Organic Chemistry, Pharmaceutics, or Pharmaceutical Sciences.

Experience with application of fundamental principles to solve complex problems.

Strong organizational skills, interpersonal skills, teamwork skills, strong written and verbal communication skills 

Ability to prioritize and manage multiple projects and activities while managing rapid project timelines 

Bonus Points If You Have (Preferred Requirements)

Experience with data structuring and data capture

Experience with prediction of small molecule physical properties and translation of molecular properties to predict formulation and bioperformance. 

Experience in pharmacokinetic modeling and simulation using Gastroplus or similar PBPK modeling software 

Experience with formulation design for preclinical studies, as well as awareness of drug product design criteria for phase 1 clinical trials

  

PHYSICAL/MENTAL REQUIREMENTS

Candidates must have the ability to perform laboratory work.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

 Intermittent/occasional travel within continental US required.

Relocation support available

Work Location Assignment: On Premise

The annual base salary for this position ranges from $90,900.00 to $151,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.

Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

Research and Development