**Research Engineer Position in Sanofi / WIDGET consortium** _Expert in Biology, Molecular Biology, Sequencing_ **Abstract:** As part of the WIDGeT consortium1 (23M€, 5 years), we are currently researching a Research Engineer candidate with a strong background in molecular biology. **Overview of the research project:** The WIDGeT consortium (Viral Vector Intelligent Design for Gene Therapy) aims to accelerate the development of gene therapies using viral vectors derived from adeno-associated viruses (AAV) for the treatment of age-related macular degeneration and hereditary podocytopathies (kidney diseases), leveraging the potential of artificial intelligence (AI). As part of this challenging consortium, our team proposed to develop a new technology to provide very sensitive information of AAV’s transgene expression at the single cell level. This technology is based on droplet microfluidic, DNA barcoded, scRT-PCR and NGS. **Responsibilities:** + Develop and optimize molecular biology protocols + Design tools (Probes, PCR primers, NGS primers, …) needed for the project + Execute complex experiments + Analyze data (Sanger) + Write (Lab Book) and Present (PowerPoint) research findings. + Report and collaborate with the other members of the team. **Qualifications :** + MS in biology/molecular biology + Strong background in molecular biology + Appetite for bench work & wet lab + Appetite for challenging project + Good written and verbal communication skills. + Experience in NGS is a plus + Experience in Single-cell RNA sequencing is a plus. + Experience in screening is a plus. + Knowledge in organoids/tissues preparation is optional. + Background in Droplet microfluidic is optional. + Experience with Recombinant AAV is optional. **The Project Team:** A dedicated team was created in 2024 to tackle this challenging project. The team is composed of one researcher, one engineer and one technician. **The Lab:** Our innovative Team (~8 people) is based in Vitry-Sur-Seine (Suburbs of Paris) at Sanofi R&D site. We have two laboratories (L1 & L2) dedicated to droplet microfluidic technology, with access to diverse technologies (ARIA Fusion (FACS), PCR, qPCR and NextSeq Illumina). **Duration & Salary:** 2-3 years **Language:** English / French (optional) **Contact:** Helene.Erasimus@sanofi.com , Guillaume.Mottet@sanofi.com **References:** 1Sanofi, WhiteLab Genomics, the TaRGeT Laboratory at Nantes University, and Institut Imagine launch WIDGeT to make France a global leader in gene therapy. | Institut Imagine (https://www.institutimagine.org/en/sanofi-whitelab-genomics-target-laboratory-nantes-university-and-institut-imagine-launch-widget) **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/) Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)