Bioinformatician (protein engineering) Job Location (Short): Plzeň, CZE, 30100 Posting Start Date: 7/16/25 Do you want to take responsibility and make a difference with your work? With your expertise, we can achieve great goals together. We are WACKER - Reliable. Determined. Ambitious. As one of the world's most research-intensive chemical companies, we've been making countless products that are an integral part of your everyday life possible for over 100 years. From vegan food to resource-efficient buildings to solar cells, we develop sustainable solutions that change the future. Bioinformatician – focused on protein engineering. Tasks / Repsonsibilities + Establishment of bioinformatic methods for predicting mutations in proteins with the aim of improving expression, solubility, stability, and activity. + Rational protein design, as well as AI-driven predictions to identify and evaluate potential hotspots for directed mutagenesis. + Utilization of molecular dynamics methods to identify important interaction surfaces using atomistic or coarse-grained simulations. + Development of internal workflows and toolkits for investigating protein-protein and protein-ligand interactions, e.g. Free energy determination. + Development of strategies to optimize regulatory elements (e.g. promoter and terminator regions) for targeted control of gene expression in various host organisms. + Evaluation of data from the fields of genomics, proteomics, and metabolomics to support microbiology groups. + Evaluation of principles and work with external partners/consultants, provide support for collaboration. + Proactive knowledge management regarding tools, methods, and best practices. + Close colaboration with the areas of molecular biology, protein biochemistry, and fermentation. + Documentation and presentation of results in project meetings. Qualifications / Requirements + M.Sc. or PhD degree in bioinformatics, structural biology, biochemistry, computational biology, or a related field. + Solid knowledge in the analysis of protein sequences and structures using computational expertise. + Experience in predicting and evaluating mutations concerning protein structure and function. + Knowledge in the analysis and optimization of regulatory DNA elements (promoters, terminators). + Strong skills in Python programming and Linux environments, knowledge of machine learning frameworks (e.g., PyTorch, TensorFlow) are an advantage. + Experience with cloud computing platforms (preferably Microsoft Azure). + Experience with Illumina and ONT sequencing data as well as bioinformatics NGS pipelines. + Team player, self-initiative, and a structured working style. + Strong problem-solving and analytical skills. + A passion for continuous learning and improvement. + Excellent English language skills. We offer + Competitive Salary (with yearly bonus up to 15%) + Opportunity for Future Growth and Advancement + Meal allowance of 123 CZK / day + Transport allowance of 100 CZK / day + Vacation allowance 10 000 CZK / year + Flexi Pass 20 000 CZK / year + Christmas allowance 10 000 CZK / year + 5 weeks of holiday and for every 3 years of employment plus 1 extra day of holiday 3 days of sick leave per year + Pension insurance contribution up to 4 166 CZK / month + Home office option ...and much more! ​ As an international company, we welcome the diversity of people. We consciously promote equal opportunities and a diverse, inclusive culture in our teams - this is what makes us successful. We look forward to receiving your application! Reference code: 29814 ​ + Start apply with LinkedIn + Apply Now Start + Please wait...