Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure. This Senior Scientist I role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs.

As one of CMC purification development scientists, you will work in the CMC purification team to develop robust, phase-appropriate processes for drug substance GMP production to enable human clinical studies and eventual licensure. This position is an onsite role in a lab-based function. To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment with daily face-to-face interactions between scientists.

Responsibilities include:

Support development, optimization, and scale-up of purification processes through lab-based and pilot plant operation activitiesSupport transfer of purification processes to GMP manufacturing for clinical material productionExecute routine purification development operations from harvest to UF/DF operations competently and independently, and generate reliable and consistent resultsAnalyze and critique experimental results, noting significant deviationsPrepare small to large (500L) batches of buffer solutions following batch record recipeSupport pilot plant activities including preparation and executionPerform routine analytical measurements using HPLC and UV-vis instrumentationAccurately record and manage multiple data sets and batch records in electronic notebooks, databases and excel filesPerform general lab maintenance including cleanliness, equipment maintenance and maintaining inventoryCollaborate within the team in order to follow best practices and meet project goalsBe flexible to participate in innovative projects with shifting priorities and ambiguity in directionLearn and understand new experimental techniquesMust be comfortable with physical activities of constant standing, walking, sitting and occasionally lifting up to 50IbsAuthor technical reports and presentations including preparing verbal updates and presentations at group meetings
Qualifications

Basic:

Bachelor’s Degree or equivalent education and typically 3 years of experience; MS or equivalent education and typically 0 years of experienceMust have hands-on protein purification experience such as chromatography separations and filtration operationsExperience with operating and programing methods for AKTA chromatographic instruments (such as AKTA Avant, AKTA Purifier, AKTA Pure or similar)Must have excellent attention to detail and ability to keep detailed written recordsAble to analyze and critique experimental results and note significant deviationsAble to work collaboratively within and outside of the groupAble to learn and understand new experimental techniquesHas a strong understanding of bioprocess engineering conceptsHas strong planning and analytical skillsHas excellent interpersonal and communication skillsProficient in scientific writing skills and verbal communication including scientific data presentationsProficient in Microsoft Office software and have the ability to learn new software applications

 

Preferred:

Has hands on experience within CMC purification development including harvest, depth filtration, virus inactivation, chromatographic membrane, resin chromatography, virus filtration, and UF/DF unit operationsHas hands on experience with monoclonal antibody or antibody-like molecule purification at GMP, pilot and/or laboratory bench scaleUnderstanding of analytical techniques, such as HPLC, LAL, and ELISA
Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​​

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The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​ Salary: ​$58,656-$107,500

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​​

This job is eligible to participate in our short-term incentive programs. ​​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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