At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Diabetes, Obesity and Complications Therapeutic Area (DOCTA) of Eli Lilly and Company, focuses on the discovery of biologic, small molecule and genetic therapeutics for the treatment of diabetes, obesity and associated complications.

We are seeking a highly motivated lab-based scientist to join our Indianapolis Diabetes/Obesity research team that is focused on developing innovative therapeutics to treat cardiovascular and renal complications associated with obesity and diabetes. The ideal candidate will have a strong background in cell and molecular biology techniques, with a preferred focus on renal cell systems and endpoints, coupled with extensive experience in in vitro and in vivo pharmacology.

Responsibilities:

Conduct in vitro and in vivo pharmacology studies to evaluate the efficacy and safety of therapeutic candidates.Use cell and molecular biology techniques, including cell culture, transfection, PCR, Western blotting, and immunohistochemistry.Design and complete experiments involving renal cell systems, including primary cell cultures and cell lines, including utilization of CRISPR/Cas9 systems to modify gene expression in cell lines.Implement experiments using different classes of drug modalities including small molecules, biologics and oligonucleotides, among others.Complete experiments and analyze data from in vivo models of renal disease including but not limited to endpoints such as glomerular filtration rate, gene and protein expression from tissue, urine and plasma.Communicate results clearly and effectively with team members and the scientific community through reports, presentations or publications and collaborate with cross-functional teams to advance drug discovery and development projects.

Minimum Qualifications:

Bachelor’s degree with 4-5+ years industry experience, or Master's degree with 0-3+ years industry experience in Pharmacology, Cell Biology, Molecular Biology, or a related field.

Additional Preferences:Experience in in vivo pharmacology, including model development and characterization, proficiency in animal handling techniques, different dosing techniques/routes (PO, IV, IP, Subcutaneous), tissue extraction and preparation for downstream analysisProficiency in cell and molecular biology techniques, including next generation western blot techniques, RT-qPCR, lentiviral overexpression systems, CRISPR/Cas9 gRNA design and experimentation, primary cell isolation and culture techniques,Experience with renal cell systems and endpoints preferred but not required.Demonstrated ability to work effectively in a team environment.Collaborate with colleagues on research projects and deploy creative analytical and problem-solving skills when necessary.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

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Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$63,000 - $162,800

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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