At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Join the rapidly expanding Lilly Gene Therapy team at Eli Lilly. We invent, characterize, and advance novel gene therapy reagents for a wide range of clinical applications, working cross-functionally across disease areas and platforms. Our goal is to deliver on the promise of gene therapy for patients worldwide.

Job Responsibilities:

Design, build and test novel CAR constructs by combining modular protein domains to support discovery-stage cell therapy programsApply molecular biology methods and protein engineering strategies to enhance construct performanceDesign and manage large-scale construct libraries (arrayed and pooled) for discovery campaignsPartner with LVV production teams to enable high-throughput testing of construct panelsWork with broader teams to quantify in vitro and in vivo outcomes from produced constructsWork cross-functionally with Lilly’s expertise in Immunology, Oncology, Computational Biology, and Genomics to advance novel cell therapy programsPartner with translational teams and CROs to test engineered CARs in primary immune cells, in vitro functional assays, and in vivo models

Basic Requirements

PhD in biology, molecular biology, or related scientific field.

Additional Preferences

Strong expertise in molecular biology techniques, including cloning, mutagenesis, PCR/qPCR/ddPCR, and sequencingExperience in protein engineering approaches such as codon optimization, linker design, and modular domain assemblyExperience with library-scale cloning or mutagenesis approaches (Golden Gate, Gibson, or similar)Familiarity with computational protein design tools is a plusExperience with primary cell engineering or in vivo models is a plusExcellent problem-solving skills and ability to troubleshoot complex issuesStrong communication and collaboration skills

Additional Information:This role may require up to 10–15% travel for conferences or training. Location: 15 Necco Street, Boston Seaport, MA 02210.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$133,500 - $217,800

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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